{"id":1549,"date":"2014-10-18T05:07:02","date_gmt":"2014-10-18T05:07:02","guid":{"rendered":"http:\/\/www.lifeandnews.com\/articles\/?p=1549"},"modified":"2016-08-08T14:59:15","modified_gmt":"2016-08-08T14:59:15","slug":"bugs-as-treatment-coming-to-a-clinic-near-you","status":"publish","type":"post","link":"https:\/\/www.lifeandnews.com\/articles\/bugs-as-treatment-coming-to-a-clinic-near-you\/","title":{"rendered":"Bugs as treatment: coming to a clinic near you…"},"content":{"rendered":"

By Paul Bertrand<\/a>, RMIT University<\/em> and Anna Walduck<\/a>, RMIT University<\/em><\/p>\n

When you\u2019re sick, you want the most effective treatment to help get you back on your feet. But what if that involved bugs?<\/p>\n

Maggots and leeches have been used for decades and are still supplied to hospitals for speciality treatments. Researchers are now investigating<\/a> whether hookworms can allow people with coeliac disease<\/a> to safely consume wheat.<\/p>\n

Leeches and maggots<\/h2>\n

Creepy crawlies have long been used for various types of treatment. Historical references from ancient Greece<\/a> show that leeches were used as far back as 270 BC, probably for bloodletting.<\/p>\n

Over the years<\/a>, leeches have been used for many purposes. With their potent secretions, leeches make microsurgery or plastic surgery more successful by preventing venous blood from collecting.<\/p>\n

\"\"
Maggots secrete a host of factors to dissolve dying tissue.<\/span>
\nAijaK\/Shutterstock<\/a><\/span><\/figcaption><\/figure>\n

The modern story of the maggot in wound healing is that one fortunate solder in the First World War was found to have survived a life-threatening wound apparently because it was covered with maggots. The maggots ate the dead and dying flesh and helped to keep the wound from becoming fatally infected.<\/p>\n

Today, wound healing is still an issue where modern medicine is not available, or where conventional therapies are ineffective, as with Bairnsdale Ulcer (Buruli ulcer) in Victoria, Australia, where \u201cmighty maggots<\/a>\u201d are being trialled as a better treatment.<\/p>\n

Although maggots are still used<\/a> in some hospitals today, your chances of having a typical wound heal with or without maggots is about the same.<\/p>\n

Worms and bacteria<\/h2>\n

Researchers first noticed that parasitic infection reduced the symptoms of inflammatory bowel diseases (IBD) in the 1980s and it\u2019s now an area of active research<\/a>. At the time, the researchers didn\u2019t know why this would be the case and a number of other factors (such as diet and living conditions) made it difficult to establish a clear cause and effect.<\/p>\n

As we learn more about how parasites work, it is becoming obvious that successful parasites came prepared with a full toolbox of chemicals. With the creepy crawlies, these tools do things like thin blood so that the leech \u2013 or mozzie \u2013 can get a better feed.<\/p>\n

\"\"
Leeches release a combinations of blood thinners and anaesthetics.<\/span>
\ngbohne\/Flickr<\/a>, CC BY-SA<\/a><\/span><\/figcaption><\/figure>\n

In the parasites, they also include molecules which interact directly with the human immune system. A parasite wants to live with you, and to do that it needs to convince your body\u2019s immune system to ignore it.<\/p>\n

Parasites that cause chronic infections have evolved ways to manipulate the immune system by switching it from high inflammation and \u201cattack\u201d mode, to low inflammation and \u201cdamage control mode\u201d. This switching may have an incidental calming effect on inflammatory diseases like IBD and coeliac disease.<\/p>\n

Interestingly, this is a similar argument for why the bacteria H. pylori<\/a> is good for you in that it may reduce the severity of IBD<\/a>. But while it could potentially be used as an edible vaccine<\/a>, the down side is the risk of gastric cancer (in addition to ulcers), so there are good reasons to heed the warning<\/a> \u201cthe only good Helicobacter is a dead Helicobacter\u201d.<\/p>\n

Hookworms to treat coeliacs<\/h2>\n

Coeliac disease<\/a> is a problem where the body\u2019s immune system attacks fairly innocuous proteins from wheat. This attack also damages the intestine and causes serious problems for sufferers, giving them few options<\/a> but to avoid gluten altogether.<\/p>\n

The immune system attack in coeliac disease is similar to what happens in IBD<\/a> \u2013 ulcerative colitis and Crohn\u2019s disease \u2013 and all three problems are often put together under the general heading of autoimmune diseases.<\/p>\n

Michael Mosley ingested a tapeworm for his BBC documentary Michael Mosley.<\/figcaption><\/figure>\n

Recently, the hookworm has been shown to release substances that calm the immune system, allowing the parasite to live peacefully in your gut. This calming effect may be helpful for IBD and recently it has been investigated against coelic disease.<\/p>\n

Researchers at Brisbane\u2019s Prince Charles Hospital tested the idea that the immune-calming effect of the hookworm could help people with coeliac disease during a small but well-designed clinical trial<\/a>. While a previous study had not found an improvement in gluten tolerance, the new study was careful to slowly increase the levels of gluten.<\/p>\n

As the researchers point out<\/a>, the level of increased tolerance achieved was not enough to allow their patients to eat a whole meal of gluten, but it was enough that accidental (or incidental) ingestion of gluten would not cause problems.<\/p>\n

Is it worth it?<\/h2>\n

Maggots secrete a host of factors to dissolve dying tissue. But it\u2019s the actual action of the maggots eating the dying tissues that does the work.<\/p>\n

With leeches, they release blood thinners and anaesthetics in a combination that has been difficult to replicate, though I believe this will be possible in the near future.<\/p>\n

With parasitic infection of the gut, do you need the actual bug \u2013 or could you take a pill containing something that the bug secretes?<\/p>\n

A handful of studies have identified molecules with immune-altering effects. But these proteins<\/a> are \u201cforeign\u201d to the human immune system and may cause inflammation or other problems in own right. So far these molecules are showing promise as vaccines<\/a> against neglected parasitic infections, but other applications may be some time off.<\/p>\n

Personally, I hope these problems can be solved because the alternative \u2013 using the whole parasite \u2013 is not only distasteful, it also comes with the risk of disease.<\/p>\n

\"The<\/p>\n

Paul Bertrand receives funding from National Health and Medical Research Council for projects relating to gastrointestinal health and disease<\/em><\/p>\n

Anna Walduck receives funding from RMIT University and NHMRC for research on infectious diseases and immunology.<\/em><\/p>\n

This article was originally published on The Conversation<\/a>.
\nRead the original article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

By Paul Bertrand, RMIT University and Anna Walduck, RMIT University When you\u2019re sick, you want the most effective treatment to help get you back on your feet. But what if that involved bugs? Maggots and leeches have been used for decades and are still supplied to hospitals for speciality treatments. Researchers are now investigating whether […]<\/p>\n","protected":false},"author":39,"featured_media":5292,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[42],"tags":[1070,1074,1072,892,885,891,860,1071,1073],"_links":{"self":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/1549"}],"collection":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/comments?post=1549"}],"version-history":[{"count":3,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/1549\/revisions"}],"predecessor-version":[{"id":5293,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/1549\/revisions\/5293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media\/5292"}],"wp:attachment":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media?parent=1549"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/categories?post=1549"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/tags?post=1549"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}