{"id":17612,"date":"2019-08-18T17:06:06","date_gmt":"2019-08-18T17:06:06","guid":{"rendered":"https:\/\/www.lifeandnews.com\/articles\/?p=17612"},"modified":"2019-08-19T00:11:53","modified_gmt":"2019-08-19T00:11:53","slug":"whats-the-scoop-on-kids-and-dirt-get-enough-to-help-but-not-enough-to-hurt-a-doctor-advises","status":"publish","type":"post","link":"https:\/\/www.lifeandnews.com\/articles\/whats-the-scoop-on-kids-and-dirt-get-enough-to-help-but-not-enough-to-hurt-a-doctor-advises\/","title":{"rendered":"What\u2019s the scoop on kids and dirt? Get enough to help, but not enough to hurt, a doctor advises"},"content":{"rendered":"

Cosby Stone<\/a>, Vanderbilt University<\/a><\/em><\/p>\n

Whenever I am asked what I do for a living, the phrase \u201cI\u2019m an allergist\u201d is almost immediately followed by \u201cSo, where are all of these allergies coming from<\/a>?\u201d<\/p>\n

Maybe I\u2019ll get sick of that question some day, but I haven\u2019t yet. As a clinician and researcher on allergies and public health, I first explain that when a society begins to become aware of a disease, the reported prevalence will go up<\/a>. This is understandable. People who have medically unexplained symptoms wonder \u201cCould I have this allergy that\u2019s being talked about?\u201d and try on the diagnosis. Sometimes an allergy really is at the root of their problems, and sometimes it\u2019s not.<\/p>\n

For example, at least 50% of patient-reported<\/a> food allergies are only presumed. They have not been evaluated thoroughly enough to know for sure whether the patient is allergic. Research also demonstrates that, in many cases, we presume wrongly. The symptoms fit better with an intolerance than an allergy, or the events were coincidental. While 11%-12% of patients currently report a food allergy, only about 5% of adults and 8% of children likely have true food allergy<\/a>. Around 8% of patients report a penicillin allergy, but fewer than five out of 100 patients<\/a> who report a penicillin allergy can be shown to be allergic when tested.<\/p>\n

Many people next ask whether allergies are genetic, but allergies in one\u2019s family appear to explain only 10%-40% of a person\u2019s<\/a> increased risk for allergies. Allergic diseases are also increasing at rates that are inconsistent with genetic diseases.<\/p>\n

More interesting is that there appear to have been different waves in which allergies appeared in historical records<\/a>. Hay fever (environmental allergies) first appeared in the 1800s, followed by more recent increases in asthma and food allergy.<\/p>\n

What\u2019s changed, and what\u2019s dirt got to do with it?<\/h2>\n
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Much of childhood eczema could be prevented by using barriers, such as petroleum jelly.<\/span>
\nall_about_people\/shutterstock.com<\/a><\/span><\/figcaption><\/figure>\n

So if genetics don\u2019t fully explain the rise in allergy, what does?
\nSome of the most consistent risk factors for allergic diseases include overuse of antibiotics<\/a>; acute viral respiratory infections<\/a> in childhood; birth by cesarean section<\/a>; nutritional disorders; second-hand smoke exposure; pollution; and the environment where you grew up<\/a><\/p>\n

To organize these risks into categories, two conceptual hypotheses currently seem to be of value \u2013 the barrier hypothesis<\/a> and the hygiene hypothesis<\/a>.<\/p>\n

Imagine that your immune system is an army behind a castle wall. The castle wall is your skin, your respiratory tract and your gastrointestinal tract. The army is composed of your white blood cells in addition to other cells in the body that can activate these gung-ho Marines to defend you.<\/p>\n

The central tenet of the barrier hypothesis is that when our skin, respiratory tract and gastrointestinal tract are chronically injured, your castle wall is broken down. The soldiers of the immune system are activated to aggressive defense, yet allergens can penetrate, and people can begin to experience allergic inflammation in those areas. This has been most clearly demonstrated with the allergic skin disease known as eczema<\/a>.<\/p>\n

Research has also shown that activities in these barrier sites can flavor the immune response and profile<\/a> of a person, especially in childhood. Many risk factors for allergic disease, such as viral infections, nutritional disorders, smoke exposure and pollution, affect the health of our barriers. Studies have indicated that up to 50% of childhood eczema,<\/a> a barrier disease, can be prevented simply by applying protective emollients like petroleum jelly to protect babies\u2019 skin when we bathe them.<\/p>\n

The role of hygiene in allergy<\/h2>\n
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Protecting babies\u2019 skin with a protective barrier can help.<\/span>
\nFotoAndalucia\/shutterstock.com<\/a><\/span><\/figcaption><\/figure>\n

The central tenet of the hygiene hypothesis is that we have gone a bit too far and inadvertently killed off our good bacteria along with the bad. As our society progressed from one that was chronically burdened with infectious diseases caused by poor sanitation, the thinking goes, we reduced our exposures to the things that gave our immune system an appropriate training and tolerance. Historically, our totally rational fear of dying from a cholera epidemic led to sewage and water management<\/a>, but may have kicked off the allergy epidemic.<\/p>\n

Our overuse of antibiotics and C-sections affects the set of organisms called the microbiome<\/a> that an infant is exposed to growing up. Both have been shown to increase the risk of childhood allergic diseases.<\/p>\n

Growing up in a rural area exposed to farm animals appears to confer a decreased risk of allergies and asthma<\/a> for your entire lifetime, even among genetically similar populations<\/a>. Studies in mice have shown that inhaling certain molecules from soil-dwelling bacteria can set off a beneficial cascade promoting an immune system which focuses more on threats rather than nonthreats, such as allergens<\/a>.<\/p>\n

Vaccinations appear to be a crucial exception to the rule of the hygiene hypothesis<\/a>. They confer protection against diseases without any associated increase in the risk of allergic disease, likely because they, unlike antibiotics, are very specifically targeting only the worst disease-causing organisms.<\/p>\n

Our current prescription<\/h2>\n

The data currently paints a picture that we might prevent allergies in the future by protecting our barriers and introducing the right tolerizing exposures at the right time<\/a>, such as early introduction of peanuts. However, I can\u2019t currently tell you how much dirt or what kinds of bacteria your child needs to safely experience while growing up. It\u2019s too soon for that, but many wonderful scientists around the world are working on these questions, thanks to support from a variety of governments and foundations.<\/p>\n

Until then, I will share with you the broad-brush advice that I currently give my friends and patients. \"The<\/p>\n