{"id":2110,"date":"2014-10-29T16:46:48","date_gmt":"2014-10-29T16:46:48","guid":{"rendered":"http:\/\/www.lifeandnews.com\/articles\/?p=2110"},"modified":"2016-08-10T01:34:32","modified_gmt":"2016-08-10T01:34:32","slug":"moms-prenatal-hardship-turns-babys-genes-on-and-off","status":"publish","type":"post","link":"https:\/\/www.lifeandnews.com\/articles\/moms-prenatal-hardship-turns-babys-genes-on-and-off\/","title":{"rendered":"Mom’s prenatal hardship turns baby’s genes on and off"},"content":{"rendered":"

By Suzanne King<\/a>, McGill University<\/em><\/p>\n

In January 1998 five days of freezing rain collapsed the electrical grid of the Canadian province of Qu\u00e9bec. The storm<\/a> left more than 3 million people without electricity<\/a> for anywhere from a few hours to 45 days \u2013 one of the worst natural disasters in Canadian history.<\/p>\n

As devastating as the ice storm and its effects were, these challenging conditions also provided an unusual research opportunity.<\/p>\n

As a professor of psychiatry, I\u2019ve long been interested in stress during pregnancy. Usually we\u2019re forced to study prenatal stress retrospectively<\/em>. Researchers have relied on databases of birth, death, and health information to conclude that exposure to major events during pregnancy, like war<\/a> or death of a relative<\/a>, increases health risks in the unborn child. Interviewing mothers many years later about stressful events that might have occurred during their pregnancies is another retrospective way to examine the question. But it still doesn\u2019t get at what it was about the stressful event that influenced the fetus\u2019s development.<\/p>\n

\"\"
How would the ice storm affect unborn babies?<\/span>
\nPregnancy image via www.shutterstock.com<\/a><\/span><\/figcaption><\/figure>\n

The challenging conditions left in the ice storm\u2019s wake provided the unusual opportunity to study prenatal stress prospectively<\/em>. Living without electricity in the middle of the Canadian winter would stress plenty of pregnant women. Instead of looking backwards, we could track effects of stress going forward in time.<\/p>\n

So in June 1998 we recruited nearly 200 women who were pregnant during the ice storm. We sent them questionnaires to measure the objective severity of the hardship they experienced (days without electricity, financial loss, injuries, moving house and so on), and also how much subjective distress they were still feeling from the disaster.<\/p>\n

Since then, we have seen that a mother\u2019s level of objective hardship predicts many outcomes: the more days she was without electricity, for example, the lower<\/a> the child<\/a>\u2019s IQ<\/a>, the greater the child\u2019s risk of becoming obese<\/a>, and the more insulin the child secreted<\/a> in a glucose tolerance test, which might set him up to develop diabetes later in life.<\/p>\n

The big surprise was that the mother\u2019s subjective experience of distress had no effect on any of these outcomes. The theory had been that prenatal maternal distress could affect the fetus\u2019 development via the mother\u2019s stress. Distress would trigger a cascade of stress hormones in her body that would then pass through the placenta to disrupt normal development of the baby. There was no room in that theory for objective hardship to have an effect on the baby without going through the mother\u2019s level of distress and her resulting stress hormones.<\/p>\n

We were perplexed: how is it that a child whose mother stayed calm and collected during the ice storm despite losing power for weeks could have worse outcomes than one whose mother was clearly distraught by the ice storm but never lost power? Our study showed it was happening, but how could objective maternal hardship \u2013 independent of subjective stress \u2013 affect these biological mechanisms? To investigate, my colleague Dr. Moshe Szyf and I started to look at the epigenetics of the ice storm kids.<\/p>\n

To understand epigenetics<\/a>, imagine that your genetic makeup is a printed sheet of music, the product of the DNA from your mother and father. Every human being has a different song printed on their score, and no one can change what has been printed.<\/p>\n

\"\"
How fast or slow is the song in your DNA played?<\/span>
\nRebecca Jasso<\/a><\/span><\/figcaption><\/figure>\n

On the other hand, any song can be played in different ways: a little faster here, a little slower there; a little louder here, but softer there. These nuances may be written on the printed score. And so it is with our DNA, which cannot be changed, but can take on different forms according to markings made on it by the environment.<\/p>\n

Methylation<\/a> is one way those markings are made on the score of DNA. Imagine that your DNA has thousands of little switches, like dimmers on lights, which slide up and down to increase or decrease the expression of those genes. The process of adding biochemicals called methyl groups to those little switches is methylation. Where these methyl groups are attached to your DNA helps determine which genes in your genome are actually expressed.<\/p>\n

We wanted to know if mothers’ objective hardship or subjective distress from the ice storm changed the way in which the babies\u2019 DNA was methylated. In 2011, 34 of the children, then 12 or 13 years old, gave blood samples. Our post-doctoral fellow Dr. Lei Cao found<\/a> that the women\u2019s objective level of hardship from the ice storm predicted the children\u2019s epigenetic profile, while their level of distress from the storm didn\u2019t predict any effect. For instance, the more times the family changed house during the crisis predicted more methylation in certain genes \u2013 regardless of the mom\u2019s subjective feeling of stress during the ice storm. As in our earlier work, the changes in the kids weren\u2019t due to their mothers\u2019 degree of emotional distress following the ice storm, but rather to factors outside of the moms’ control, such as the number of days without electricity.<\/p>\n

Though small, our study showed the 1998 ice storm created sufficient hardship for pregnant women that it caused epigenetic changes in their unborn children that have lasted at least 13 years \u2013 that\u2019s pretty permanent! No other study had previously shown epigenetic effects linked to objective hardship rather than subjective distress.<\/p>\n

The objective severity of the mothers’ hardship most affected the methylation of two kinds of genes in the ice storm kids: immune system genes, which might increase risk for asthma and allergies, and metabolism genes, which might affect risk of obesity or diabetes. Our next challenge is to figure out how these epigenetic changes actually affect the children\u2019s health. And a remaining big question is how did the mothers’ experiences produce these altered patterns of gene expression?<\/p>\n

\"The<\/p>\n

Suzanne King, Ph.D. receives funding from The Canadian Institutes of Health Research (CIHR).<\/em><\/p>\n

This article was originally published on The Conversation<\/a>.
\nRead the original article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

By Suzanne King, McGill University In January 1998 five days of freezing rain collapsed the electrical grid of the Canadian province of Qu\u00e9bec. The storm left more than 3 million people without electricity for anywhere from a few hours to 45 days \u2013 one of the worst natural disasters in Canadian history. As devastating as […]<\/p>\n","protected":false},"author":39,"featured_media":5434,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[36],"tags":[311,1174,1177,1178,269,892,885,891,860,1176,1175,228,1179],"_links":{"self":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/2110"}],"collection":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/comments?post=2110"}],"version-history":[{"count":2,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/2110\/revisions"}],"predecessor-version":[{"id":5433,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/2110\/revisions\/5433"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media\/5434"}],"wp:attachment":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media?parent=2110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/categories?post=2110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/tags?post=2110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}