{"id":21519,"date":"2020-07-29T23:01:19","date_gmt":"2020-07-29T23:01:19","guid":{"rendered":"https:\/\/www.lifeandnews.com\/articles\/?p=21519"},"modified":"2020-07-31T02:01:59","modified_gmt":"2020-07-31T02:01:59","slug":"bloodthirsty-tsetse-flies-nurse-their-young-one-live-birth-at-a-time-understanding-this-unusual-strategy-could-help-fight-the-disease-they-spread","status":"publish","type":"post","link":"https:\/\/www.lifeandnews.com\/articles\/bloodthirsty-tsetse-flies-nurse-their-young-one-live-birth-at-a-time-understanding-this-unusual-strategy-could-help-fight-the-disease-they-spread\/","title":{"rendered":"Bloodthirsty tsetse flies nurse their young, one live birth at a time \u2013 understanding this unusual strategy could help fight the disease they spread"},"content":{"rendered":"

Geoff Attardo<\/a>, University of California, Davis<\/a><\/em><\/p>\n

Tsetse flies are bloodthirsty. Natives of sub-Saharan Africa, tsetse flies can transmit the microbe Trypanosoma<\/em> when they take a blood meal. That\u2019s the protozoan that causes African sleeping sickness in people<\/a>; without treatment, it\u2019s fatal, and millions of people are at risk due to the bite of a tsetse fly.<\/p>\n

My entomology research<\/a> focuses on insects that feed on the blood of people and animals. From a human health standpoint, understanding what makes all these bugs tick is key to developing ways to control them and prevent transmission of the diseases they carry, such as malaria, dengue, Lyme disease, West Nile virus and many others.<\/p>\n

Tsetse flies stand out from their blood-feeding cousins the mosquitoes and ticks because of their unique reproductive biology. They give birth to live young and, even more unusual, the mother lactates and provides milk for her offspring. Here\u2019s how it all works \u2013 and why their unusual reproduction strategy might be a key to controlling tsetse flies and the parasite they carry once and for all.<\/p>\n

From egg to larva<\/h2>\n

Scientists know of other flies that hold onto their eggs in their reproductive tract until they hatch into young larvae, with each brood consisting of dozens of offspring. The mother then tries to find a suitable source of nutrition in the environment, deposits the larvae<\/a> and leaves them to survive on their own. The mother does not provide any nutrition for her young.<\/p>\n

That\u2019s the standard fly way of life. Tsetse flies take a different approach<\/a>.<\/p>\n

\"pregnant<\/a>
A pregnant tsetse fly with a larva visible in her uterus.<\/span>
\nGeoffrey M. Attardo, University of California, Davis<\/span>, CC BY-ND<\/a><\/span><\/figcaption><\/figure>\n

Female tsetse flies develop just one single egg at a time<\/a>. When the egg is complete, the mother moves it from her ovaries into her uterus in a process called ovulation. Once in the uterus, the egg is fertilized with sperm the female has stored in an organ called the spermatheca. While females can mate multiple times, they obtain all the sperm they need for their lifetime from a male fly during a single mating event.<\/p>\n

After fertilization, the female keeps the egg in her uterus<\/a> for five days while an embryo develops within the egg. When the embryo is ready, the egg hatches in the uterus of the female and the tsetse fly larva begins its life living inside its mother\u2019s uterus<\/a>.<\/p>\n

Milk meals for baby<\/h2>\n

Here\u2019s where tsetse flies dramatically diverge from most other insects.<\/p>\n

Attached to the mother\u2019s uterus is a specialized gland that makes a milk-like substance<\/a>. The organ is called the milk gland, and it produces a rich mixture of fats and particular proteins that provide the larva with all the nutrition it needs to develop into an adult.<\/p>\n

\"In<\/a>
Tsetse larva surrounded by the milk gland (stained pink in this image) and fat storage tissues.<\/span>
\nGeoffrey M. Attardo, University of California, Davis<\/span>, CC BY-ND<\/a><\/span><\/figcaption><\/figure>\n

Amazingly, many tsetse milk proteins<\/a> are very similar in function<\/a> to those found in the milk produced by mammals.<\/p>\n

Just like in mammals, the milk also transfers beneficial bacteria<\/a> from the mother to the offspring. These bacteria are essential<\/a> for tsetse flies, and without them adult female flies are unable to reproduce<\/a>.<\/p>\n

After five or six days of developing and feeding on milk, the larva is fully grown and ready to enter the world. The mother finds a safe spot and gives birth. The larva immediately burrows underground to avoid predators and parasites.<\/p>\n

Once buried, the outer surface of the larva\u2019s skin hardens and turns black, forming a protective shell. This is called the pupal stage and it lasts for around three weeks. During this time, the pupa transforms into an adult fly.<\/p>\n

\"Adult<\/a>
A new adult fly emerges from the pupa in sandy earth. Adult flies are about equivalent in size to the common housefly.<\/span>
\nPatrick Robert\/Sygma via Getty Images<\/a><\/span><\/figcaption><\/figure>\n

It then emerges from the pupa, climbs out of the ground, and begins its life as an adult tsetse fly looking for hosts to blood-feed on and other tsetse flies to mate with.<\/p>\n

Why live birth?<\/h2>\n

Why would an insect evolve this slow and resource-intensive way to reproduce?<\/p>\n

One idea is that this method provides a defensive advantage relative to free-living larvae against parasites and predation. Larvae on their own have few (if any) ways to defend against these threats. But keeping larvae in the mother\u2019s uterus provides shelter and a guaranteed food source. While this strategy is much slower, scientists think the extra maternal care results in higher larval survival rates<\/a>. It\u2019s a matter of quality over quantity.<\/p>\n

[Get facts about coronavirus and the latest research.<\/em> Sign up for The Conversation\u2019s newsletter.<\/a>]<\/p>\n

A result of this reproductive strategy is that tsetse fly populations are small and slow to recover from control efforts, relative to more prolific insects like mosquitoes.<\/p>\n

My colleagues and I hope that we can parlay our understanding of the molecular processes that regulate tsetses\u2019 milk production and mating behavior into new environmentally friendly, cost-effective and tsetse-specific control strategies for these insects.<\/p>\n

The sleeping sickness tsetse flies spread is a potential issue for millions of people in 36 sub-Saharan countries<\/a>, though the number of annual cases has decreased drastically thanks to major control efforts \u2013 including trapping flies, applying insecticides and releasing sterile males to the environment<\/a> where they mate with wild females but don\u2019t produce offspring. Ultimately, we\u2019d like to contribute to the World Health Organization\u2019s goal of eliminating African sleeping sickness by 2030<\/a> with a new way to prevent the transmission of disease-causing trypanosomes to people and animals.\"The<\/p>\n

Geoff Attardo<\/a>, Assistant Professor of Entomology and Nematology, University of California, Davis<\/a><\/em><\/p>\n

This article is republished from The Conversation<\/a> under a Creative Commons license. Read the original article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Geoff Attardo, University of California, Davis Tsetse flies are bloodthirsty. Natives of sub-Saharan Africa, tsetse flies can transmit the microbe Trypanosoma when they take a blood meal. That\u2019s the protozoan that causes African sleeping sickness in people; without treatment, it\u2019s fatal, and millions of people are at risk due to the bite of a tsetse […]<\/p>\n","protected":false},"author":44,"featured_media":21520,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3410],"tags":[8422,5203,4114,8420,8425,214,4252,7130,8417,8424,8419,8421,8418,8423],"_links":{"self":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/21519"}],"collection":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/comments?post=21519"}],"version-history":[{"count":2,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/21519\/revisions"}],"predecessor-version":[{"id":21531,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/21519\/revisions\/21531"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media\/21520"}],"wp:attachment":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media?parent=21519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/categories?post=21519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/tags?post=21519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}