{"id":25117,"date":"2021-04-17T19:28:00","date_gmt":"2021-04-17T19:28:00","guid":{"rendered":"https:\/\/www.lifeandnews.com\/articles\/?p=25117"},"modified":"2021-04-18T01:27:35","modified_gmt":"2021-04-18T01:27:35","slug":"astrocyte-cells-in-the-fruit-fly-brain-are-an-on-off-switch-that-controls-when-neurons-can-change-and-grow","status":"publish","type":"post","link":"https:\/\/www.lifeandnews.com\/articles\/astrocyte-cells-in-the-fruit-fly-brain-are-an-on-off-switch-that-controls-when-neurons-can-change-and-grow\/","title":{"rendered":"Astrocyte cells in the fruit fly brain are an on-off switch that controls when neurons can change and grow"},"content":{"rendered":"\n

Sarah DeGenova Ackerman<\/a>, University of Oregon<\/a><\/em><\/p>\n\n\n\n

The Research Brief<\/a> is a short take about interesting academic work.<\/em><\/p>\n\n\n\n

The big idea<\/h2>\n\n\n\n

Neuroplasticity \u2013 the ability of neurons to change their structure and function in response to experiences<\/a> \u2013 can be turned off and on by the cells that surround neurons in the brain, according to a new study<\/a> on fruit flies that I co-authored.<\/p>\n\n\n\n

As fruit fly larvae age, their neurons shift from a highly adaptable state to a stable state and lose their ability to change. During this process, support cells in the brain \u2013 called astrocytes \u2013 envelop the parts of the neurons<\/a> that send and receive electrical information. When my team removed the astrocytes, the neurons in the fruit fly larvae remained plastic longer, hinting that somehow astrocytes suppress a neuron\u2019s ability to change. We then discovered two specific proteins that regulate neuroplasticity.<\/p>\n\n\n\n

\"Fruit<\/a>
As fruit flies develop, special cells surround their neurons and seem to halt neuroplasticity. Sarah DeGenova Ackerman, CC BY-ND<\/a><\/figcaption><\/figure>\n\n\n\n

Why it matters<\/h2>\n\n\n\n

The human brain is made up of billions of neurons that form complex connections with one another. Flexibility at these connections is a major driver of learning and memory<\/a>, but things can go wrong if it isn\u2019t tightly regulated. For example, in people, too much plasticity at the wrong time is linked to brain disorders such as epilepsy<\/a> and Alzheimer\u2019s disease<\/a>. Additionally, reduced levels of the two neuroplasticity-controlling proteins we identified are linked to increased susceptibility to autism<\/a> and schizophrenia<\/a>.<\/p>\n\n\n\n

Similarly, in our fruit flies, removing the cellular brakes on plasticity permanently impaired their crawling behavior. While fruit flies are of course different from humans, their brains work in very similar ways to the human brain and can offer valuable insight.<\/p>\n\n\n\n

One obvious benefit of discovering the effect of these proteins is the potential to treat some neurological diseases. But since a neuron\u2019s flexibility is closely tied to learning and memory, in theory, researchers might be able to boost plasticity<\/a> in a controlled way to enhance cognition in adults<\/a>. This could, for example, allow people to more easily learn a new language or musical instrument.<\/p>\n\n\n\n

\"A<\/a>
In this image showing a developing fruit fly brain on the right and the attached nerve cord on the left, the astrocytes are labeled in different colors showing their wide distribution among neurons. Sarah DeGenova Ackerman, CC BY-ND<\/a><\/figcaption><\/figure>\n\n\n\n

How we did the work<\/h2>\n\n\n\n

My colleagues and I<\/a> focused our experiments on a specific type of neurons called motor neurons. These control movements like crawling<\/a> and flying<\/a> in fruit flies. To figure out how astrocytes controlled neuroplasticity, we used genetic tools to turn off specific proteins in the astrocytes one by one and then measured the effect on motor neuron structure. We found that astrocytes and motor neurons communicate with one another using a specific pair of proteins called neuroligins and neurexins. These proteins essentially function as an off button for motor neuron plasticity<\/a>.<\/p>\n\n\n\n

What still isn\u2019t known<\/h2>\n\n\n\n

My team discovered that two proteins can control neuroplasticity, but we don\u2019t know how these cues from astrocytes cause neurons to lose their ability to change.<\/p>\n\n\n\n

Additionally, researchers still know very little about why neuroplasticity is so strong in younger animals and relatively weak in adulthood<\/a>. In our study, we showed that prolonging plasticity beyond development can sometimes be harmful to behavior<\/a>, but we don\u2019t yet know why that is, either.<\/p>\n\n\n\n

What\u2019s next<\/h2>\n\n\n\n

I want to explore why longer periods of neuroplasticity can be harmful. Fruit flies are great study organisms for this research because it is very easy to modify the neural connections in their brains<\/a>. In my team\u2019s next project, we hope to determine how changes in neuroplasticity during development can lead to long\u2013term changes in behavior.<\/p>\n\n\n\n

There is so much more work to be done, but our research is a first step toward treatments that use astrocytes to influence how neurons change in the mature brain. If researchers can understand the basic mechanisms that control neuroplasticity, they will be one step closer to developing therapies to treat a variety of neurological disorders.<\/p>\n\n\n\n

[Understand new developments in science, health and technology, each week.<\/em> Subscribe to The Conversation\u2019s science newsletter<\/a>.]<\/p>\n\n\n\n

Sarah DeGenova Ackerman<\/a>, Postdoctoral Fellow, UO Institute of Neuroscience and Howard Hughes Medical Institute, University of Oregon<\/a><\/em><\/p>\n\n\n\n

This article is republished from The Conversation<\/a> under a Creative Commons license. Read the original article<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Sarah DeGenova Ackerman, University of Oregon The Research Brief is a short take about interesting academic work. The big idea Neuroplasticity \u2013 the ability of neurons to change their structure and function in response to experiences \u2013 can be turned off and on by the cells that surround neurons in the brain, according to a […]<\/p>\n","protected":false},"author":44,"featured_media":25118,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3410,8],"tags":[3521,263,329,7296,3265,9782,1224,1161,1688,9781,232,5714,2197,7727,257],"_links":{"self":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/25117"}],"collection":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/users\/44"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/comments?post=25117"}],"version-history":[{"count":2,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/25117\/revisions"}],"predecessor-version":[{"id":25124,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/posts\/25117\/revisions\/25124"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media\/25118"}],"wp:attachment":[{"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/media?parent=25117"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/categories?post=25117"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lifeandnews.com\/articles\/wp-json\/wp\/v2\/tags?post=25117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}